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fentanyl intranasal and pentobarbital both improve sedation. Avoid or Use Alternate Drug. Limit use to sufferers for whom option procedure solutions are insufficientpentobarbital will lessen the extent or outcome of buprenorphine buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.Anticoagulants: Phenobarbital lowers